Clinical Trial for Medication for Geographic Atrophy

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Older person with Blue Eye
Older Person with Blue Eye

Medically reviewed by Sefy Paulose, MD

What is Geographic Atrophy?

As noted on APH VisionAware, ā€œAge-Related Macular Degeneration (AMD) is a gradual, progressive, painless deterioration of the macula, which is the small area in the center of the retina that gives us our detailed vision.ā€ Geographic Atrophy (GA) is the most advanced form of dry AMD and involves patches of cells that have degenerated or died off in the macula, which is the central part of vision. Atrophy refers to the degeneration of the retinal pigment epithelium (RPE). Geographic refers to the shape of the atrophied portion of the retina.

According to GATHER2, the website for the GATHER2 Clinical Trial, ā€œIndividuals with dry AMD or wet AMD can develop GA. GA often affects both eyes. There is no US Food and Drug Administration (FDA)ā€“approved treatment for GA.ā€ Individuals may experience blind spots, distortions, and other changes in vision as GA progresses.

Possible Other Symptoms Related to GA:

  • Gradual loss of central vision
  • Difficulty recognizing faces
  • Difficulty with
    • Distinguishing color
    • Adjusting from bright to dim lighting
    • Depth perception
    • Close work (threading a needle, reading, cooking, etc.)
    • Driving
    • Watching TV

According to the GATHER2 website, you do not have to be experiencing all of these symptoms to qualify for the clinical trial.

About the GATHER2 Clinical Trial

According to the company website, GATHER2 is aĀ phaseĀ 3Ā trialĀ testing a potential treatment known as ZimuraĀ®Ā (avacincaptad pegol). A phase 3 trial is one of the final testing phases typically required for a treatment to be approved by theĀ USĀ FoodĀ andĀ DrugĀ AdministrationĀ (FDA).

Through the trial, doctors want to find out if ZimuraĀ® can help slow down the progression of geographic atrophy (GA) and to determine potential side effects of the medication

GATHER2 was designed based on the completed GATHER1 phase 3 clinical trial results.

Clinical Trial Procedures

Initially, trial participants will be randomly placed into two groups.

  • Group 1 participants will receive ZimuraĀ® 2 mg eye injections once a month.
  • Group 2 participants will receive a sham procedure[SC1]  meant to simulate an injection once a month. The sham group will not get an injection into the eye.

At the beginning of Year 2, those in the ZimuraĀ® group will be randomly placed into two new groups.

  • Some participants will continue to receive ZimuraĀ® once a month.
  • Some participants will receive ZimuraĀ® once every other month.

Patients in the sham group will remain in the sham group.

Two eye doctors will monitor participants throughout the trial monthly.

How to Participate

First, talk to your doctor. 

Read the doctor discussion guide.  Key points include:

  • Find out if you have geographic atrophy
  • Find out about risks and benefits, other options, and clinical trials in your area
  • Financial costs
  • Eligibility for the trial

Contact for Participating in the Clinical Trial

If you want to participate in the GATHER2Ā ClinicalĀ Trial, please callĀ 1-833-ZIMURA2Ā (1-833-946-8722)Ā toll-free anytime. Call between 9:00 AM and 5:00 PM Eastern Monday through Friday to talk to someone.


If you call after hours or during the weekend, leave a message for a return call.

Note about ZIMURA: ā€œGATHER2 IS SPONSORED BY IVERIC bio, WHICH IS LOCATED IN THE UNITED STATES. ZIMURAĀ® IS AN INVESTIGATIONAL PRODUCT AND HAS NOT BEEN APPROVED BY THE FDA. SAFETY AND EFFICACY OF ZIMURAĀ® FOR AGE-RELATED MACULAR DEGENERATION AND GEOGRAPHIC ATROPHY HAVE NOT BEEN ESTABLISHED. PLEASE SPEAK TO YOUR DOCTOR ABOUT PARTICIPATING IN THIS TRIAL. Copyright Ā© 2021 IVERIC bio, Inc. All rights reserved._DTP_GATHER2_Discussion Guide_28FEB2021.ā€

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